The independent predictors were: age (HR: 1.05, 95% CI: 1.04-1.07), marital status (divorced/widowed/separated HR: 1.13, 95% CI: 0.85-1.50 compared to married; never married HR: 2.06, 95% CI: 1.19-3.58), CHF (HR: 1.58, 95% CI: 1.12-2.24), CHD (HR: 1.45, 95% CI: 1.04-2.01), stroke (HR: 1.41, 95% CI: 1.01-1.98), taking insulin (HR: 1.31, 95% CI: 1.01-1.71), and creatinine levels (HR: 1.00, 95% CI: 1.00-1.00) (Supplementary Table S1). This evidence concerns the gene INS and congestive heart failure.