To better account for the potential impact of fat distribution, we replaced BMI-based obesity with waist circumference-based abdominal obesity, similar findings were observed in the effects of metabolically healthy phenotypes on serum Klotho levels (MUO: -4.4% [-7.3% to -1.4%], Supplementary Table S2). The gene discussed is KL; the disease is obesity due to melanocortin 4 receptor deficiency.