For example, Wnt2, Wnt7, and disheveled segment polarity protein 3 (DVL‐3) are upregulated in tumors, while negative regulators like naked cuticle homolog 1 (NKD1) and NKD2 are significantly downregulated, underscoring the crucial role of the Wnt pathway in HBV‐related tumor development [451]. Here, DVL3 is linked to neoplasm.