Key signaling pathways in the malignant transformation from viral hepatitis to HCC include NF‐κB, JAK/STAT, PI3K/AKT, MAPK, NRF2, Hippo, Wnt/β‐catenin, p53, VEGF, and IGF (Figure 3). Here, NFKB1 is linked to hepatocellular carcinoma.