PP2A interacts with protein arginine methyltransferase 1 (PRMT1) to inhibit its activity, thereby preventing PRMT1 from catalyzing the methylation of arginine 3 on histone H4, which regulates gene transcription and further disrupts epigenetic regulation, driving HCC progression [106, 107, 108]. Here, PRMT1 is linked to hepatocellular carcinoma.