Moreover, circRNA_100338 is closely associated with the metastatic progression of HBV‐related HCC, promoting tumor cell migration and invasion by sponging miR‐141‐3p and regulating metastasis suppressor 1 (MTSS1), whose downregulation is linked to increased metastatic potential in HCC, making the circRNA_100338/miR‐141‐3p/MTSS1 axis essential for HBV‐related HCC progression [274]. The gene discussed is MTSS1; the disease is neoplasm.