NQO1 and liver disorder: Studies have shown that upregulation of NRF2‐regulated genes, such as NADPH quinone oxidoreductase 1 (NQO1), GSH‐Px, and glutamate cysteine ligase (GCLC), strengthens antioxidant defenses, modulates proteasomal activity, reduces viral antigen presentation, and diminishes T‐cell recognition, allowing HBV‐infected cells to survive immune surveillance, thereby promoting chronic infection and worsening liver disease [438, 439].