In chronic infection, macrophages gradually shift toward the immunosuppressive M2 phenotype, with M2 macrophages, especially tumor‐associated macrophages (TAMs), promoting immune evasion in the tumor microenvironment by secreting inhibitory cytokines such as IL‐10 and TGF‐β, thereby fostering immune escape and tumor growth [376]. The gene discussed is TGFB1; the disease is neoplasm.