For instance, stigmasterol has been shown to modulate diversity of the intestinal microbiota and significantly enhance populations of Lactobacillus johnsonii, Lactobacillus murinus, and Lactobacillus reuteri, leading to a reduced Treg/CD8+ T cell ratio, which enhances immune responses within the tumor microenvironment [638]. The gene discussed is CD8A; the disease is neoplasm.