In addition, due to the complexity of NETs formation and the diversity of their components, several substances can directly or indirectly act on NETs and may become precursors for the treatment of IBD, such as DNase 1 acting on cf‐DNA, selective PAD4 inhibitors like Cl‐amidine, ROS scavengers like N‐acetylcysteine, MPO inhibitors like PF1355, and endogenous NETosis inhibitors like prostaglandin E2.353, 355, 363. Here, MPO is linked to inflammatory bowel disease.