Inhibition of the activation of STAT1, HMGB1–TLR2/TLR4, PI3K‐γ, Raf1–MEK‐1–Erk can alleviate the clinical symptoms of various diseases caused by NETs such as SLE, RA), microscopic polyangiitis (MPA), and so on.115, 116, 117, 118. The gene discussed is RAF1; the disease is microscopic polyangiitis.