In addition, PAD4−/− breast cancer mice can reduce the volume and weight of primary tumors and lung metastases due to the disorder of NETs formation,86 and targeted inhibition of PAD4 expression can significantly improve the clinical symptoms and disease progression of Crohn's disease (CD), multiple myeloma, acute pancreatitis, and lupus model mice.87, 88, 89, 90. The gene discussed is PADI4; the disease is plasma cell myeloma.