Another study demonstrated that fibrinogen, an autoantigen identified in NETs, induces the release of inflammatory cytokines from RA synovial fibroblasts and enhances the expression of PAD4 and receptor activator of NF‐kB ligand in RA synovial fibroblasts, suggesting that autoantigens in NETs, such as fibrinogen, may play a critical role in activating and amplifying the inflammatory response in RA.278. The gene discussed is PADI4; the disease is rheumatoid arthritis.