Inhibition of the activation of STAT1, HMGB1–TLR2/TLR4, PI3K‐γ, Raf1–MEK‐1–Erk can alleviate the clinical symptoms of various diseases caused by NETs such as SLE, RA), microscopic polyangiitis (MPA), and so on.115, 116, 117, 118. This evidence concerns the gene TLR4 and rheumatoid arthritis.