In CRC, dysregulation of the PR domain containing 2 transcript and overexpression of retinoblastoma interacting zinc finger protein 2 correlate with malignancy, where retinoblastoma interacting zinc finger protein 2 modulates tumor behavior through the epidermal growth factor (EGF)/epidermal growth factor receptor (EGFR) pathway, enhancing EGF secretion and influencing tumor immunosuppression and angiogenesis [48]. Here, EGF is linked to neoplasm.