Proteomic and metabolomic studies have demonstrated that several key glycolytic enzymes and transporters—such as hexokinase (HK), phosphofructokinase, lactate dehydrogenase (LDH), and glucose transporter (GLUT)—are upregulated in CRC, correlating with poor prognoses [86]. The gene discussed is SLC2A1; the disease is colorectal carcinoma.