Additionally, angiopoietin‐like 4, S100 calcium binding protein A2, ADP‐ribosyltransferase 1, and rndoplasmic reticulum membrane protein 1 are implicated as cancer drivers in CRC, primarily by activating the PI3K/AKT pathway, which enhances glucose metabolism reliance in tumor cells, sustaining elevated GLUT1 levels and malignant progression [88, 89, 90, 91]. The gene discussed is AKT1; the disease is colorectal carcinoma.