ACLY and colorectal carcinoma: Recent findings indicate that Catenin Beta 1 (CTNNB1) may play a role in this process; both ACLY and CTNNB1 are highly expressed in CRC, and their interaction (ACLY–CTNNB1 complex) significantly enhances the transcriptional activity of CTNNB1, facilitating CRC cell proliferation and metastasis [104].