MAPT and Pick disease: To assess whether it is also the case in tauopathy diseases, we performed Western blot analysis of total and phospho-Tau levels in the hippocampus of PS19 transgenic mice and medial frontal cortices of human tauopathy patients including corticobasal degeneration (CBD), Picks disease, and progressive supranuclear palsy (PSP) (Supplementary Figure S1).