AKT1 and chronic kidney disease: Notably, a number of additional shared pathways were identified from enrichment analysis of Factors 2 and 3, including the PI3K/Akt signaling pathway, MAPK signaling pathway, NF-κB signaling pathway, Rap1 signaling pathway, and axon guidance, suggesting the MOFA factors are independently capturing orthogonal features in CKD that are shared across multiple pathways.