Notably, a number of additional shared pathways were identified from enrichment analysis of Factors 2 and 3, including the PI3K/Akt signaling pathway, MAPK signaling pathway, NF-κB signaling pathway, Rap1 signaling pathway, and axon guidance, suggesting the MOFA factors are independently capturing orthogonal features in CKD that are shared across multiple pathways. Here, NFKB1 is linked to chronic kidney disease.