Concordant with the increased inflammatory signal, there was a downregulation in mRNA expression of genes linked to neurodevelopment and myelination, neurotransmitter regulation, and psychiatric disorders including calcium binding Calb2 and S100b, as well as SNAP25, Pvalb, MAG, Olig1, and Olig2 (Figure 3). The gene discussed is PVALB; the disease is psychiatric disorder.