IRF8 and infection: The response to infection included upregulation of multiple genes linked to interferons (Ifna, Ifnb, Ifng, Irf7, Irf8, Mx1, Stat1 and Bst2), inflammation (Il6,Tnfa), complement (Cfb,C1ra,C2, C3), cytolysis (Gzma, Gzmb, Prf1) consistent with antiviral responses and inflammation together with neuroprotective regulatory signals (Il27, Il10, and stat2).