The IL‐10 anti‐inflammatory signaling pathway involving IL‐10 and HMOX1 was higher in HF, whereas the IL‐10 signaling pathway was lower in HF, led by 10 proteins (IL1RN, CCL22, CSF1, CCL20, IL10RB, IL12B, TIMP1, TNFRSF1B, ICAM1, and TNFRSF1A). The gene discussed is IL10RB; the disease is hydrops fetalis.