SMOC1 and early-onset autosomal dominant Alzheimer disease: RSPO3 is an important determinant of the peripheral adipose tissue storage capacity (Garritson and Boudina 2021; Loh et al. 2020), while SMOC1 appears to be consistently identified as a key protein in Alzheimer's disease, as multiple proteomic studies have found higher SMOC1 in brain tissue and CSF, as well as associations with amyloid pathology (Roberts et al. 2023).