GCLC and Familial prostate cancer: GCLC (involved in glutathione biosynthesis from glutamate), GSR (involved in the conversion of oxidized glutathione to reduced glutathione), and NQO1 (involved in the reduction of quinones to hydroquinones) have all been reported to be overexpressed in many types of cancer, including renal, lung, and prostate cancers [42, 43].