On the other hand, the increase in D2 level that we observed when FAPs initiate adipocyte differentiation induces an increase in TH that could in turn attenuate Wnt-β-catenin and/or Hedgehog pathways (a mechanism we previously demonstrate to occur in colon cancer cells and keratinocytes, respectively (29, 30)). The gene discussed is DIO2; the disease is colonic neoplasm.