As shown in Figure 5G, the AUC valueof CD66b/CD63+ NEVs to differentiate between HC and GCwas 0.790, while miR-223-3p and miR-425-5p were 0.861 and 0.853, respectively.Moreover, the combination of three NEV biomarkers (NEV signatures)showed better differentiation of HC and GC, with an AUC of 0.891 (83.58%of sensitivity and 84.51% of specificity). This evidence concerns the gene CEACAM8 and gastric cancer.