Variables, encompassing comorbidities such as metabolic acidosis, diabetes mellitus, and hypertension, alongside biochemical markers indicative of disease severity including WBC counts, Cr levels, ALB levels, P_24 h, Hb levels, glomerular filtration rate (GFR), P_0 h, and severity indices such as CCI, APACHE II, SOFA as well as general conditions such as SBP, DBP, MAP, urine output, mechanical ventilation, and BMI were identified as potential predictors of 90-day mortality in the univariate analysis (p < 0.05). The gene discussed is GSTM1; the disease is metabolic acidosis.