Clinical studies on hormone supplementation include treatments such as allopregnanolone and isoflavones for AD.529–531 Other hormone-related treatments include GHRH supplementation in healthy elderly individuals and patients with mild cognitive impairment, and this treatment has favourable effects on cognition and metabolism.532 Previous studies have associated growth hormone administration for one year with an average reduction in BA of 2.5 years, as assessed by four epigenetic clocks.533. The gene discussed is GHRH; the disease is Alzheimer disease.