MAPT and dementia: Aβ deposition initiates a series of downstream pathological events, such as tau pathology, oxidative stress, and energy metabolism disorders, ultimately resulting in synaptic or neuronal degeneration and eventually dementia.30,87 This linear hypothesis elucidates the major pathologic outcomes that arise from imbalances in homoeostasis at various scales, from the molecular to the cellular and ultimately to the organ layers, as well as the interconnections among them.