Additionally, peripheral inflammatory markers, including IL-2, IL-17A, IL-12p70, tumour necrosis superfamily member 8 (TNFRSF8) and tumour necrosis factor (TNF)-α, are associated with neurodegeneration in individuals with FTLD, such as brain atrophy and abnormal metabolism, which are mainly distributed in frontal‒temporal regions.337 Subsequent intensive research even suggested that plasma IL-6 and TNF-α levels may be positively correlated with the rate of cognitive decline.338. This evidence concerns the gene TNF and Mental deterioration.