HTT and Huntington disease: For example, low levels of phagocytosis and autophagy, as well as the secretion of inflammatory factors by microglia, are associated with the noncell-autonomous toxicity of astrocytes.95 Furthermore, HD is a progressive neurodegenerative disorder with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline, and behavioural difficulties.96 The pathogenesis of HD primarily stems from an abnormally expanded CAG repeat near the N-terminus of the Huntingtin gene, resulting in the production of mutant HTT (mHTT) protein.