SERPINE1 and cancer: Given that PAI-1 facilitates tumor cell detachment from the matrix and promotes tumor dissemination and metastasis, which has been recommended as a promising biomarker for poor prognosis in primary breast cancer patients by the American Society of Clinical Oncology (ASCO) and the European Organization for Research and Treatment of Cancer (EORTC) clinical operation guidelines [22, 23], we selected SERPINE1 as a primary target for further study.