PAI-1 facilitates tumor cell detachment from the matrix and promotes tumor dissemination and metastasis and has been recommended as a promising biomarker for poor prognosis in primary breast cancer patients by the American Society of Clinical Oncology (ASCO) and the European Organization for Research and Treatment of Cancer (EORTC) clinical operation guidelines [22, 23]. The gene discussed is SERPINE1; the disease is neoplasm.