CD4 and neoplasm: For example, Lee et al. incorporated a Glu-urea-Lys PSMA-targeting ligand into the LNP system, resulting in increased LNP accumulation at tumor sites.231 Ramishetti et al. constructed tLNPs that can specifically deliver nucleic acids to CD4( + ) T lymphocytes by chemically conjugating mAbs against CD4 to the LNPs.