KDM5B and nasopharyngeal carcinoma: KDM5B is a well-known histone demethylase and master regulator of histone modifications that functions as a key mediator of chromatin organization, transcriptional control, and genome stability, all of which are critical for tumor progression across various malignancies.25 Consistently, our ChIP-seq analysis revealed substantial changes in KDM5B occupancy across promoters at genome-wide level upon manipulating KDM5B expression in NPC.