Conversely, KDM5B overexpression led to the activation of the signaling cascade in these cells (Fig. 7c and Supplementary Fig. 9c), consistent with the finding in prostate tumor progression.30 However, introducing PLK2 overexpression alongside KDM5B overexpression attenuated this activation (Fig. 7c and Supplementary Fig. 9c). This evidence concerns the gene PLK2 and prostate neoplasm.