The multivariate and mediation analysis showed that CRP (β −0.01) and interleukin‐1β (−0.005) contributed to the reduction of CT in the medial orbitofrontal region (Table S3), but they did not mediate the effect of MDD, as the effect size did not decrease in the multivariate model (β −0.016). Here, CRP is linked to major depressive disorder.