Elevated levels of PE 16:0_20:4 and PE 18:2_16:0 have been highlighted in studies on critical illness and inflammation (32), and Vianello et al. (2024) suggest that circulating PEs including PE 34:2, PE 38:5 are associated with the DAMP-induced NLRP3 inflammasome in cardiovascular disease patients with insulin resistance risk (33). This evidence concerns the gene NLRP3 and Insulin resistance.