Subretinal inflammation is a strong component of retinopathy progression in different RD models (age-related macular degeneration (AMD), diabetic retinopathy (DR)) (21, 22, 23, 24, 25), including other models of RD associated with lipid dysregulations such as the Mfp2−/− and Mfsd2a−/− mouse models (9, 26). Here, HSD17B4 is linked to diabetic retinopathy.