For example, in PCa, MCT4-mediated lactate promotes the expression of the vascular endothelial growth factor A (VEGFA) by inducing lactylation of HIF-1α and suppresses the expression of semaphorin 3 A (Sema3A), which supports the transcription of Cell migration-inducing protein (CEMIP, KIAA1199) and enhances angiogenesis [84]. This evidence concerns the gene SEMA3A and posterior cortical atrophy.