Since Pten/PI3K/AKT signaling, Nrf2 signaling and ERp57/calcium signaling are reported to be canonical pathways in osteoclast differentiation and significantly influence osteoclast behaviors under various pathological conditions [42–44] our results, therefore, depict a strong correlation between the therapeutic mechanisms of Quercetagetin in RA and the impact on inflammatory osteolysis. The gene discussed is PDIA3; the disease is rheumatoid arthritis.