In > 30year age group, relative expression of GPX4, HAMP, A2M (P < 001), HP and FTHI (P < 0.01) was significantly downregulated while NCOA4 was upregulated (P < 0.05) in PCOS patients compared to healthy control subjects of same age group (Fig. 2C). Here, GPX4 is linked to polycystic ovary syndrome.