UBC and amyotrophic lateral sclerosis: Thus, we established the Tdp-43∆NLS model of ALS by crossing heterozygous Tdp-43∆NLS± mice strain with TAM-inducible Ubc (whole body, WB) or Mnx1 (motor neuron, MN)-specific promoter-driven Cre± mice as shown in schematics (Fig. 2C).