Thereby, we were able to generate two different types of murine Tdp-43∆NLS mice models of ALS: one with inducible Cre-mediated WB-Tdp-43∆NLS expression and the other with developmentally regulated Mnx1-driven Cre expression-mediated MN-Tdp-43∆NLS in post-mitotic neurons in the CNS. The gene discussed is MNX1; the disease is amyotrophic lateral sclerosis.