UBC and amyotrophic lateral sclerosis: The bigenic Cre::Tdp-43∆NLS mice suffered from progressive motor dysfunctions, gait asymmetry, early-stage myogenic ALS pathology, and MN degeneration, simultaneously, pTDP‐43- and ubiquitin‐positive pathology in the dorsolateral and dorsoventral spinal cord, reflected early ALS symptoms [69].