The 18 common pathways were pathogenic Escherichia coli infection, rheumatoid arthritis, arachidonic acid metabolism, Fc gamma R-mediated phagocytosis, oxytocin signaling pathway, GnRH signaling pathway, the C-type lectin receptor signaling pathway, serotonergic synapses, thermogenesis, the regulation of lipolysis in adipocytes, renin secretion, the peroxisome proliferator-activated receptor (PPAR) signaling pathway, bile secretion, inflammatory mediator regulation of TRP channels, circadian entrainment, vitamin digestion and absorption, fat digestion and absorption, and taste transduction. The gene discussed is GNRH1; the disease is rheumatoid arthritis.