Among them, 14 were involved in the pathogenic Escherichia coli infection pathway (Fig. 8A), six in the rheumatoid arthritis pathway (Fig. 8B), two in the PPAR signaling pathway (Fig. 8D), two in the bile secretion pathway (Fig. 8E), four in the GnRH signaling pathway (Fig. 8C), and one in the fat digestion and absorption pathway (Fig. 8F). The gene discussed is GNRH1; the disease is rheumatoid arthritis.