Although total S1PR1 levels were reduced in MASH and HCC mouse models (Fig.S10), its expression level was significantly upregulated in hepatic ECs (Fig. 7B) along with an increase of its high-affinity natural agonist S1P-d18-1 in the serum and the liver (Fig. 3). This evidence concerns the gene S1PR1 and hepatocellular carcinoma.