Interestingly, Sptlc2 (serine palmitoyltransferase, long chain base subunit 2), a critical subunit of the enzyme serine palmitoyltransferase, was upregulated in hepatocytes, immune cells, and macrophages but downregulated in cholangiocytes, HSCs, and ECs in HCC group. Here, SPTLC2 is linked to hepatocellular carcinoma.