IL-19 antibody treatment increased the percentages of MC04_Mo/Mφ_2 and MC06_Mo/Mφ_3 in both TMZ-sensitive and TMZ-resistant GBM cells (Fig. 5A), suggest that blocking IL-19 promoted the Mo/Mφ subsets differentiation into MC04_Mo/Mφ_2 and MC06_ Mo/Mφ_3 cells, which are associated with anti-tumor IFN-γ signaling (Table 1). This evidence concerns the gene IL19 and glioblastoma.