Cytokine array analysis demonstrated that IL-19 antibody treatment increased the expression of TH1-related cytokines (IFN-γ and IL-12) and TH2 cytokines (IL-4) and inhibited the expression of tumor invasion-related factors (WISP1 and IL-33) [28, 70] in tumor tissues compared with isotype control antibody treatment (Fig. 3D). This evidence concerns the gene CCN4 and neoplasm.