The genes and gene programs related to viral carcinogenesis and innate immunology, including Epstein-Barr virus infection, IL17signalling pathway and PI3K-AKT signalling pathway, were enriched in the crucial cluster according to the KEGG gene set analysis (Fig. 2e and Supplementary Fig. 2a). This evidence concerns the gene AKT1 and Epstein-Barr virus infection.