CTNNB1 and hepatocellular carcinoma: Moreover, overexpression of SMYD3, a methyltransferase responsible for H3K4me3, has been linked to the elevated expression of key proto-oncogenes such as MYC, CTNNB1, and STAT3, as well as the CDK2 gene, all of which are associated with increased tumor size and intrahepatic metastasis in murine models of HCC [58, 60].