Likewise, inhibiting protein arginine methyltransferase 5 (PRMT5) in cell cultures and biopsies from HBV-induced HCC has shown effectiveness in reducing the dimethylation of arginine 3 on histone H4 of the covalently closed circular DNA (cccDNA) minichromosome. The gene discussed is PRMT5; the disease is hepatocellular carcinoma.