Additionally, Furuta et al. used HCC cell lines with benign liver tissues as controls and found reduced expression of miR-124 upregulated CDK6, VIM, SMYD3, and IQGAP1. Also, reduced miR-203 levels upregulated ABCE1. These activated pathways led to HCC growth and metastasis [106]. This evidence concerns the gene SMYD3 and hepatocellular carcinoma.