CD8A and neoplasm: TME consists of cancer cells, including CSCs, along with a diverse array of non-tumor cells such as stromal cells, and a variety of infiltrating immune cells, including CD8 + T cells, regulatory T cells (Tregs), B cells, natural killer (NK) cells, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and dendritic cells (DCs) (Fig. 3).