IL1RL2 and colorectal carcinoma: IL-38 also effectively inhibits IL-36 cytokine-induced expression of inflammatory chemokines including CXCL1, CXCL2 and CXCL9 in HT29 and T84 CRC cells in a dose-dependent manner via disruption of IL-36R NF-κB/MAPK signalling [59].