IL1B and neoplasm: In addition, the expression of several pro-inflammatory cytokines and chemokines such as IL-1β, IL-22, TNF-α, CXCL1, CXCL2, CCL17 and CCL20 were reduced in IL-38KO mice [97], suggesting that IL-38 promotes tumour growth and development in cSSC through promoting an inflammatory tumour environment.