[63–65, 69] In a murine model of colorectal cancer (CRC), subcutaneous injection of IL-36α overexpressing CT26 cells resulted in a significant reduction in tumour weight, volume, decreased lung metastasis, and increased infiltration of CD3+CD8+ TILs compared to the control CT26 cell tumours [70]. The gene discussed is CD8A; the disease is neoplasm.