Moreover, in a murine study in CRC exploring the suitability of direct intra-tumoral delivery of IL-36γ, IL-23 and the T-cell costimulatory ligand OX40 (OX40L) mRNAs [81] showed activation and proliferation of various immune cell types including natural killer T (NKT) cells, δγ T cells, CD4+, and CD8+ T cells, in addition to inhibiting metastasis, promoting TIL activity, and improving the efficacy of checkpoint blockade therapy [81]. Here, CD4 is linked to colorectal carcinoma.