TP53 and cancer: From a survival standpoint, we found samples with TP53 frameshift mutations, TP53 R273C, and TP53 R248Q mutations to have significantly worse overall survival compared to samples with wildtype TP53. This is consistent with a recent analysis by Pal et al. that characterized the phenotypes of cancer cell lines expressing common missense p53 mutations and found p53 R273C and R248Q mutants to be among the most aggressive (in addition to R248W and Y220C)35.