Altogether, these results demonstrate that targeting the aberrant LKB1-cIAP1-JAK1 trimolecular complex, such as using an IAPi birinapant, restores STING expression in LKB1-mut tumors and leads to enhanced cytotoxic T cell infiltration and immune-dependent anti-tumor activity in an immune-competent mouse model. The gene discussed is JAK1; the disease is neoplasm.