TP53 and cancer: First, we found that WRJ388, a mouse tumor-derived cancer cell line isolated from our KrasG12D/Lkb1-/-/p53WT GEMM36, has downregulated STING expression as compared to KW634 cells60 (KrasG12D/Lkb1WT/p53-/-) (Supplementary Fig. S11A, B).