STK11 and neoplasm: LKB1-mut LUAD has been characterized to exhibit an immune suppressive phenotype with multiple immune-cold features, such as low PD-L1 expression, low tumor mutational burden, altered proinflammatory cytokine profiles, reprogrammed immune infiltration, remodeled extracellular matrix, and recently demonstrated STING expression downregulation9,27–29,32–36.