STING1 and neoplasm: These results suggest that IAP inhibition not only restores STING expression but also reactivates STING-mediated DNA-sensing signaling in response to cytosolic DNA and 2’,3’-cGAMP, which could be induced by an IAP inhibitor or IFNγ treatment (Supplementary Fig. S8), or may arise from LKB1-mut tumor intrinsic genome instability51.