To further ascertain the role of menin in regulating the transcription of lysosomal genes in lung cancer, we established a genetically engineered mouse model (GEMM) with genotypes including wild-type (WT), alveolar type II cell (ATII)-specific Men1 knockout (KO) (Men1f/f; Sftpc-Cre (MS)), ATII-specific KrasG12D mutation (LSL-KrasG12D/+; Sftpc-Cre (KS)), and ATII-specific KrasG12D mutation combined with Men1 KO (LSL-KrasG12D/+; Men1f/f; Sftpc-Cre (KMS)) [9]. Here, MEN1 is linked to lung carcinoma.