ITSN1 and Parkinson disease: Although PD tends to be more prevalent among males, this trend does not always extend to genetic forms of the disease.20–22 We thus assessed the rates of PD across male and female ITSN1 PTV carriers in the UKB, AMP-PD, and 100kGP cohorts, including individuals who were originally excluded in the collapsing analysis during the sex balancing step.