ITSN1 and Parkinson disease: We next looked to Mantis-ML for orthogonal support of the association between ITSN1 and PD (https://pages.scp.astrazeneca.net/cgr/mantisml).26 Briefly, this semi-supervised machine-learning framework estimates the probability of genes being associated with different phenotypes included in the Human Phenotype Ontology, using known disease-associated genes as “seed genes.” It leverages numerous features, including a knowledge graph, gene expression data, reported mouse phenotypes, and genic intolerance.