Combining evidence from the UKB and three replication cohorts, the association between ITSN1 and PD was statistically unequivocal (Cochran-Mantel-Haenszel [CMH] test p = 4.54 × 10−12; OR [95% CI] = 9.6 [5.4, 16.0]). The gene discussed is ITSN1; the disease is Parkinson disease.