Out of 890 multi-ancestry PD patients in this cohort, we identified three heterozygous ITSN1 PTV carriers (c.455_456dup:p.Ala153Glnfs*43, c.1909C>T:p.Arg637*, and c.1713del:p.Leu572*). Here, ITSN1 is linked to Parkinson disease.