Here, we show that primary bone marrow-derived osteoclasts similarly express elevated levels of mRNA encoding the chemokines, CXCL1, CXCL2, CXCL5, CCL2, CCL4, and CCL7, following S. aureus challenge and we subsequently confirmed the robust secretion of these leukocyte chemoattractant proteins by these cells as rapidly as four hours following infection. The gene discussed is CXCL1; the disease is infection.