Alternatively, it was clear that treatment with orientin was able to reverse palmitate-induced hepatic insulin resistance in part by improving substrate utilization, for example, it enhanced glucose uptake and effectively modulated the expression of genes coding for glucose transport (Glut2) and insulin signaling (Irs1 and PI3k) (Stanford and Goodyear 2014). The gene discussed is SLC2A2; the disease is Insulin resistance.