IRS1 and Insulin resistance: Meanwhile, there is already evidence indicating that dietary flavones, particularly the C-glycosyl flavone isomers, orientin and isoorientin, can improve glucose metabolism in cultured adipocytes (Ku et al. 2014; Ziqubu et al. 2020a; Ziqubu et al. 2020b), Moreover, orientin increased the expression of Irs1, Pi3k, and Glut2, and increased glucose uptake to potentially alleviate insulin resistance (Mazibuko-Mbeje et al. 2021).