This study aims to investigate the relationship between serum secreted frizzled‐related protein 5 (SFRP5), apolipoprotein A‐I (ApoA‐I), high‐density lipoprotein 3‐cholesterol (HDL3‐C) and in‐stent restenosis (ISR) after percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) and their combined predictive value. This evidence concerns the gene SFRP5 and myocardial infarction.