Our previous work revealed that Plac1 expression was associated with immunosuppressive TME and could be a prognostic indicator of poor outcomes in ICI cohorts.[24] Importantly, in this study, we did not only reveal how Plac1+ tumor cells induce Treg‐related immunosuppressive TME, but also discovered an interaction loop between Plac1+ tumor cells and Tregs. This evidence concerns the gene PLAC1 and neoplasm.