In the meantime, Plac1+ tumor cells shape a Treg‐related immunosuppressive microenvironment via CXCL11/CXCR3 and PVR/TIGIT, which in turn activates the tumorigenic signaling of Plac1+ tumor cells via LTA/LTBR and forms a reciprocal protumor loop. Here, LTBR is linked to neoplasm.