CD4 and neoplasm: In addition, we also conducted coculture assays of tumor cells with CD8+ T cells and macrophages according to a previous report to evaluate whether Plac1 expression influences the phenotypes of CD8+ T cells and macrophages.[53] However, no significant differences were observed in the expression of CD8+ T cell exhaustion markers or immunosuppressive marker expression in macrophages between groups, which indicated that the Plac1‐associated immune regulatory effects were specific to CD4+ T cells (Figure S13D–G, Supporting Information).