Activated M2 Mφs typically expresses high levels of CD163, and matrix metalloproteinases (MMP) like MMP9 and MMP19, thereby aiding in cell adhesion and promoting tumor growth.[47] Importantly, we also observed the upregulation of subtype‐specific genes such as SPP1, C1QA, C1QB, C1QC, AQP9, and THBS1 in Tri condition compared to CoMφ (Figure S8B, Supporting Information). This evidence concerns the gene SPP1 and neoplasm.