TLR4 and cancer: Activating TLR‐4 on cancer cells can increase the secretion of IL‐6 and enhance invasion abilities.[60] In addition, it has been firmly established that TLR‐4 expression regulates integrin expression, effectively aiding in adhesion and invasion.[61] Additionally, L–R pair analysis revealed 111 common pairs between Nichenet and CellChat (Figure S10 and Table S20, Supporting Information).