CD163 and neoplasm: Activated M2 Mφs typically expresses high levels of CD163, and matrix metalloproteinases (MMP) like MMP9 and MMP19, thereby aiding in cell adhesion and promoting tumor growth.[47] Importantly, we also observed the upregulation of subtype‐specific genes such as SPP1, C1QA, C1QB, C1QC, AQP9, and THBS1 in Tri condition compared to CoMφ (Figure S8B, Supporting Information).