EGR1 and cancer: Furthermore, as shown in a Sankey plot (Figure 7B(ii)), comparison of Tri versus CoMφ identified two highly downregulated downstream genes in cancer cells, early growth response 1 (EGR1) and zinc finger protein (ZFP36), which have been reported to be downregulated in patients with TNBC.[63] These findings further demonstrate the clinical relevance of our 3D TMEC model.