Integrin‐based cell surface receptors play a key role in promoting cancer cell invasion and migration through ECM remodeling, and overexpression of ITGAV has been reported in breast cancer as well.[57] We speculated that activation of the EDIL3–ITGAV axis could potentially evade immune cell function and promote migration of cancer cells through integrin‐based ECM remodeling. This evidence concerns the gene ITGAV and cancer.