Importantly, pathway enrichment analysis showed upregulation of hallmark cancer pathways such as IL‐6, JAK STAT3, NOD‐like receptor, and inflammatory response, consistent with previous studies.[76] Furthermore, assessment of transcriptomic changes of cancer cells in the presence and absence of CAFs and Mφs revealed the involvement of KYNU gene particularly in Tri condition. This evidence concerns the gene STAT3 and cancer.