While our current sample size was not sufficient to demonstrate significant differences in lactonase levels between ILD and no ILD patients, low PON1 lactonase activity associated with severe IIM-ILD (DLCO \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\:\le\:$$\end{document} 40%) compared to IIM patients with mild ILD or no ILD in a prior study with larger numbers [16]. Here, PON1 is linked to interstitial lung disease.