CARHSP1 and posterior cortical atrophy: However, treatment with Bay11-7085 (a NF-κB inhibitor) could significantly attenuate the downregulation of p-p65 and PD-L1 expression caused by CARHSP1 knockdown, which suggest that the decreased level of p-p65 was at least partially responsible for the impact of CARHSP1 on PD-L1 expression in PCa cells (Fig. 6E and F).