Consistently, in the present study, we found that NF-κB pathway and JAK/STAT3 pathway were down-regulated by CARHSP1 knockdown and rescued by IL-17 A stimulation, indicating that the downstream pathways of IL-17RA were affected by CARHSP1 and supporting that CARHSP1 promote cancer progression through regulation on IL-17RA. The gene discussed is NFKB1; the disease is cancer.