However, treatment with STATTIC (a STAT3 inhibitor) could significantly attenuate the downregulation of p-STAT3 expression and pathway-related downstream proteins expression caused by CARHSP1 knockdown and have no effect on the expression of CARHSP1, which verified that JAK-STAT3 signaling pathway was activated by CARHSP1 in PCa cells (Fig. 5B and C). The gene discussed is STAT3; the disease is posterior cortical atrophy.