To explore whether CARHSP1 maintains the activation of STAT3 and promotes PCa growth via IL-17RA, 22Rv1 and PC-3 cells were treated with recombinant human IL-17 A after CARHSP1 knockdown and western blotting analysis showed that the JAK-STAT3 signaling pathway was reactivated after IL-17 A treatment (Fig. 5D). The gene discussed is CARHSP1; the disease is posterior cortical atrophy.