CEACAM5 and pancreatic ductal adenocarcinoma: We first investigated a model of pancreatic ductal adenocarcinoma (PDAC) hepatic metastases, which involves intraportal injection of murine K8484 PDAC cells genetically engineered to express green fluorescent protein (GFP) and carcinoembryonic antigen (CEA) (K8484/GFP/CEA), into immunocompetent mice.