Thus, the anti-tumor effects of 5a-HSA observed in the murine models of pancreatic ductal adenocarcinoma, prostate cancer, mammary adenocarcinoma, and fibrosarcoma may reflect the ability of 5a-HSA to recognize both αvβ6 and αvβ8 on all these cells, including Tregs, and block their function. The gene discussed is ALB; the disease is fibrosarcoma.