In our study, an evident total effect of the GC response on the expression of Ac-H3 or Ac-H4 was observed without adjusting for the expression of NF-κB, suggesting that in PNS patients, GC treatment could potentially affect the expression of Ac-H3 and Ac-H4 without the involvement of NF-κB. The gene discussed is NFKB1; the disease is paraneoplastic neurologic syndrome.