Some of these Mendelian HL genes i.e., CEACAM16, COL11A2, EYA4, MYO6, POU4F3, SIX1, SLC26A5, and TECTA, have previously been shown to be implicated in ARHL by both our research and others [7, 9]. The gene discussed is SIX1; the disease is Hodgkins lymphoma.