Consistently, PI4KB-Peptide-1 mediated inhibition of PI4KB phosphorylation on S256 and T263 (Fig. 8a), and therefore hindered RINCAA, including LC3 lipidation (Fig. 8b, c), autophagic flux determined by mitophagy (Fig. 8d, e), and WIPI2 puncta formation, across various RAS-mutated cancer cell lines (Fig. 8f, g). This evidence concerns the gene WIPI2 and cancer.