Mechanistic analysis identified a ULK1-regulated phosphorylation of K251–K269 region located on PI4KB as a special event of RINCAA (Fig. 5), which is in line with several studies showing ULK1 as a major regulator of autophagy in response to different cancer signals in tumor and the potency of ULK1 inhibitors against tumor.40,119,120. This evidence concerns the gene PI4KB and neoplasm.