Inhibition of MEK1/2 and PI4KB phosphorylation on S256 and T263 in combination effectively suppressed autophagy and inhibited the proliferation of RAS-mutant tumor cell lines, and tumor growth in xenograft and LSL-KrasG12D, p53F/F, Pdx1-Cre mice (KPC) pancreatic cancer models. Here, PDX1 is linked to neoplasm.