PI4KB and cancer: In addition to promoting autophagy, RAS mutations have been reported to increase macropinocytosis, facilitating enhanced nutrient uptake in cancer cells.121–123 Although chloroquine has been shown to inhibit both autophagy and macropinocytosis, PI4KB depletion similarly inhibits both processes (Fig. 2; Supplementary information, Figs. S3, S6i, j).