TP53 and neoplasm: The aims of this study were i) to comprehensively and objectively characterize the composition of tumor-immune microenvironment landscape at a spatial level, ii) explore its distribution according to TP53 mutational status and iii) evaluate relevant prognostic implications by using automated, ML-based and multispectral spatial imaging approaches in the context of a large randomized phase III trial at the neoadjuvant setting10.