A delineation of the transcriptome and senolytic responses in a broad panel of 13 cancer cell lines induced to TIS by alisertib and etoposide—the so-called cancer SENESCopedia—recently revealed that the most unresponsive model to ABT-263/navitoclax was the colon cancer cell line LoVo [30], which harbors biallelic frameshift mutations in BAX [69, 70]. The gene discussed is BAX; the disease is cancer.