T3 promoted phosphorylation of Raptor at Ser792 and mTOR at Ser2448, while THRSP activated Raptor phosphorylation at Ser792 but inhibited mTOR phosphorylation at Ser2448 and HIF-1α nuclear translocation in HCC cells (Fig. 4A). The gene discussed is RPTOR; the disease is hepatocellular carcinoma.