SOX18 acts as a transcriptional activator to upregulate the expression of CXCL12 and PD-L1 in liver cancer cells, thereby recruiting TAMs and Tregs and suppressing the anti-tumor immune response.646 In hepatocellular carcinoma, integrated multi-omics analyses have revealed that three key transcription factors—ILF2, YBX1, and HMGA1—are regulated by the long non-coding RNA HCG18. The gene discussed is SOX18; the disease is liver cancer.