The ANXA1 protein on the large oncosomes binds to FPR+ macrophage precursors in the microenvironment, driving their differentiation into immunosuppressive Arg1hi CD206+ TAMs, further assisting CSCs in establishing a TGF-β-rich microenvironment.539 Pan-cancer analysis has revealed that Family with sequence similarity 109, member B (FAM109B) is significantly elevated across various tumor types and is associated with poor prognosis. This evidence concerns the gene TGFB1 and neoplasm.