To solve it, another team used an elongation factor short promoter and the ubiquitous chromatin opening CBX3 element to reduce epigenetic methylation and set up a scalable differentiation system to generate CAR-iMacs that efficiently eradicate CD19-positive leukemia.1063 In mouse models, the CD19-CAR-iMacs effectively eradicated CD19-positive leukemia cells, significantly inhibiting tumor growth and improving survival rates of the treated mice. Here, CBX3 is linked to leukemia.