Anti-IL-7 antibodies affect the production of cytokines by T helper cells (Th)1 and Th2 and promote macrophage polarization towards M2, thus reducing myocardial damage.834 Endothelial cells produce small extracellular vesicles (EVs) containing KLF2 that alleviate mouse myocardial ischemic injury by inhibiting the recruitment of Ly6Chi monocytes.835 The caspase recruitment domain family member 9 (CARD9) can upregulate macrophage expression of lipocalin 2 (LCN2) and MMP9, leading to myocardial cell apoptosis and adverse remodeling after MI.836. Here, CARD9 is linked to myocardial infarction.