CALR and neoplasm: Furthermore, RRX-001 reduced CD47 protein levels to prevent the immune escape of calreticulin-rich cancer cells by enhancing phagocytosis of tumor cells by macrophages.1092 In osteosarcoma (OS), RRX-001 and a sonosensitizer IR780 were combined with PEG-PCL nano micelles and OS cell membranes to assemble a biomimetic nano-drug, MPIRx.