Particularly, a subset of monocytes expressing Tie2, termed Tie2-expressing monocytes (TEMs), are a crucial source of angiogenic TAMs within tumor tissues.592–595 These cells are chemotactically attracted by angiopoietin-2 (ANG2) derived from tumor endothelial cells (EC),594,596 and their interaction with ECs stimulates further expression of Tie2 in TAMs. The gene discussed is ANGPT2; the disease is neoplasm.