Both in vivo and in vitro studies have shown that NACP@CD47 could improve tumor immunosuppression by promoting phagocytosis of macrophages/microglia and increasing M1-type polarization of TAMs.1091 Guo et al. use a layered double hydroxide nanosheet carrier to deliver a CD47 inhibitor RRX-001 and a T-type calcium channel inhibitor TTA-Q6 into lung tumors. This evidence concerns the gene CD47 and neoplasm.