TGFB1 and neoplasm: Macrophages that ingest apoptotic bodies containing tumor cell DNA activate the interferon-inducible protein AIM2, thus upregulating their expression of PD-L1 and IDO481 and promoting the synthesis of TGF-β and IL-10 through activation of LXR and RXR by the lipid components of tumor apoptotic fragments.480 Although apoptotic tumor cells can induce TAM immune tolerance to some extent, avoiding inflammatory damage also promotes tumor immune evasion.