Furthermore, in gliomas, the reduced level of glycolysis in TAMs is often associated with poor patient prognosis.497 Although M2 TAMs show an increased tendency for glycolysis in breast and pancreatic cancers, even if they compete with tumor cells for nutrients like glucose, TAMs still favor tumor invasion and growth.507,508 Interestingly, tumor cells and TAMs form a compartmentalized metabolic unit where tumor cells secrete lactate and CSF-1. The gene discussed is CSF1; the disease is neoplasm.