TGFB1 and neoplasm: It could decrease tumor invasiveness and reprogram the TIM via promoting proinflammatory macrophage polarization.1102 Nanoparticles loaded with an antihelminthic drug, Niclosamide (Ncl) (Ncl-NPs), could prevent and reverse pulmonary fibrosis by inhibiting M2-type macrophage polarization and blocking TGF-β/Smad and STAT3 signaling pathways.1103