CD8A and neoplasm: In tumor, LIC-mediated immunogenic photodynamic therapy(PDT) synergistically work with MDSCs-targeting immunotherapy, which could promote the DC maturation and CD8 + T cell infiltration, simultaneously reduce the infiltration of MDSCs, immunosuppressive Tregs, and M2-type TAMs, resulting in the inhibition of tumor growth.1097 Song et al. designed an albumin nanoparticle named Nano-PI.