Additional genes identified to be downregulated in Mif-2–/–Apoe–/– livers by this transcriptome analysis encompassed for example 17β-hydroxysteroid dehydrogenase type 13 (Hsd17b13), a gene that is significantly upregulated in the liver of patients with MASLD and that enhances lipogenesis; the transcript for Oxysterol-binding protein-related protein 3 (Osbpl3), an intracellular hepatocyte lipid receptor; or the cytochrome P450 monooxygenase Cyp4a12a, which is involved in fatty acid metabolism and generation of oxylipins including omega-oxidized fatty acids (Supplementary Fig. 18). Here, APOE is linked to metabolic dysfunction-associated steatotic liver disease.